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The Nucleic Acid Database: A resource for nucleic acid science.

H M Berman1, C Zardecki, J Westbrook

  • 1NDB, Department of Chemistry, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854-8087, USA. berman@adenine.rutgers.edu

Acta Crystallographica. Section D, Biological Crystallography
|March 25, 1999
PubMed
Summary
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The Nucleic Acid Database (NDB) provides data on nucleic acid structures and query tools. Its underlying technology has also enabled the creation of other macromolecular databases.

Area of Science:

  • Structural Biology
  • Bioinformatics
  • Molecular Biology

Background:

  • The Nucleic Acid Database (NDB) serves as a critical repository for structural information concerning nucleic acids.
  • Access to comprehensive and well-organized structural data is essential for advancing research in molecular biology and drug discovery.

Purpose of the Study:

  • To detail the information content and query functionalities of the Nucleic Acid Database (NDB).
  • To illustrate the broader impact of the NDB's technological developments on the creation of other macromolecular databases.

Main Methods:

  • Database curation and information retrieval system design.
  • Analysis of query logs and user access patterns.
  • Case studies of technology transfer to other database projects.

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Main Results:

  • The NDB offers a rich collection of nucleic acid structure data with robust query capabilities.
  • The technological framework developed for the NDB has proven adaptable and effective for other structural biology databases.
  • Demonstrated successful application of NDB technology in the development of databases for proteins and other macromolecules.

Conclusions:

  • The Nucleic Acid Database (NDB) is a valuable resource for structural biology research.
  • The NDB's technological innovations have significantly contributed to the field of bioinformatics and macromolecular data management.
  • The adaptability of NDB's technology highlights its foundational importance in building diverse biological databases.