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Updated: Aug 10, 2026
In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
Published on: October 15, 2013
[A pulmonary cellular immunity study in HIV patients]
E Fernández Fabrellas1, E González Constán, M Marín González
1Servicio de Neumología, Hospital Dr. Peset Aleixandre, Valencia.
Background:
Cellular immunity disorder, showed by a decreased blood level of lymphocytes T CD4, is the main indicator of progression in HIV infection. The diminished level of these lymphocytes and CD4/CD8 ratio in pulmonary samples obtained by bronchoalveolar lavage (BAL) is known, so as the enhanced level of lymphocytes T CD8, while the pulmonary diseases high incidence in these patients could be due to a local immunity disorder or systemic one remains unknown. The aim of this study is to compare systemic immunity disorders, studied in blood samples, with local immunity replay, showed by BAL samples, in patients with HIV infection.
Methods:
74 HIV patients were studied, all of them hospitalized due to acute respiratory disease, and undergone to fiberoptic bronchoscopy for diagnosing. Cellular and lymphocytic populations are compared and measured by flow cytometry in blood and BAL samples.
Results:
Percentage of total lymphocytes and CD4+ population were decreased in BAL samples, above all in patients with CD4 level minor than 25%.
Conclusions:
Cellular immunity disorder of patients with HIV infection is bigger in lung than in blood. It's possible to foresee the lymphocytes T CD4+ pulmonary depletion from their blood levels.
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