Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[A pulmonary cellular immunity study in HIV patients].

E Fernández Fabrellas1, E González Constán, M Marín González

  • 1Servicio de Neumología, Hospital Dr. Peset Aleixandre, Valencia.

Anales De Medicina Interna (Madrid, Spain : 1984)
|March 25, 1999
PubMed
Summary

HIV infection impairs cellular immunity, particularly T CD4 lymphocytes, more severely in the lungs than in the blood. Pulmonary T CD4 depletion can be predicted by blood T CD4 levels in HIV patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

French AFU Cancer Committee Guidelines - Update 2022-2024: Non-muscle-invasive bladder cancer (NMIBC).

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2022
Same author

French AFU Cancer Committee Guidelines - Update 2022-2024: Muscle-Invasive Bladder Cancer (MIBC).

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2022
Same author

French AFU Cancer Committee Guidelines - Update 2022-2024: Upper urinary tract urothelial cancer (UTUC).

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2022
Same author

[Guidelines from the cancer committee of the French Association of Urology (CC-AFU) for adequate intravesical instillations of Mitomycin C, Epirubicin, and BCG for non-muscle invasive bladder cancer].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2022
Same author

[Artificial urinary sphincter in patients with urinary incontinence after High Intensity Focused ultrasound].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2022
Same author

[Guidelines from the cancer (CC-AFU) and infection disease (CI-AFU) committees of the French Association of Urology for the management of adverse events and complications of BCG].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2022

Area of Science:

  • Immunology
  • Infectious Diseases
  • Pulmonology

Background:

  • Cellular immunity, marked by low T CD4 lymphocyte counts, indicates HIV progression.
  • Pulmonary T CD4 lymphocyte levels and CD4/CD8 ratios are diminished in HIV patients.
  • The cause of high pulmonary disease incidence in HIV patients (local vs. systemic immunity) is unclear.

Purpose of the Study:

  • To compare systemic immune disorders in blood samples with local immune responses in bronchoalveolar lavage (BAL) samples from HIV-infected patients.
  • To investigate the extent of cellular immunity impairment in the lungs versus the blood of HIV patients.

Main Methods:

  • Studied 74 HIV patients hospitalized with acute respiratory disease.
  • Utilized fiberoptic bronchoscopy for diagnosis.

Related Experiment Videos

  • Compared cellular and lymphocytic populations using flow cytometry in blood and BAL samples.

    • Main Results:

    • Total lymphocyte percentages and CD4+ populations were decreased in BAL samples.
    • This decrease was more pronounced in patients with blood CD4 levels below 25%.

    Conclusions:

    • HIV infection causes a greater cellular immunity disorder in the lungs than in the blood.
    • Pulmonary T CD4+ lymphocyte depletion can be predicted by their blood levels.