Related Experiment Videos
Shigella infection in macaque colonies: case report of an eradication and control program
1Department of Veterinary Services, University of Oxford, United Kingdom.
Abstract:
A primate colony comprising three distinct but interrelated units had long-term history of undiagnosed diarrhea and associated deaths for many years. In 1989, the clinical problem was recognized as a confounding factor for the experimental work, and steps were taken to eradicate the disease. This was done by a combined approach involving improved sample collection techniques and microbiological methods, treatment of all animals in the colony, and improvement in management. These management changes included alterations in basic facility and cage design, disinfection procedures, and continuous routine microbiological sampling of all groups of animals on a random basis, as well as sampling of those suspected to be at risk for stress-associated Shigella shedding. Using this approach, we have eliminated clinical cases of shigellosis and have not have any further isolations of Shigella from this colony.
Insights
A comprehensive eradication strategy successfully eliminated shigellosis in a primate colony. This involved improved diagnostics, treatment, and enhanced facility management, preventing further disease outbreaks.
Area of Science:
- Primate Colony Management
- Infectious Disease Eradication
- Veterinary Microbiology
Background:
- A long-standing issue of undiagnosed diarrhea and mortality in a primate colony impacted experimental research.
- The clinical problem was identified as a significant confounding factor in 1989, necessitating intervention.
Purpose of the Study:
- To implement and evaluate a strategy for eradicating shigellosis from a primate colony.
- To improve animal health and ensure the integrity of experimental research by controlling infectious disease.
Main Methods:
- A multi-faceted approach combining improved sample collection and microbiological techniques.
- Colony-wide treatment of animals and significant enhancements in facility and cage design.
- Implementation of rigorous disinfection protocols and continuous, routine microbiological sampling.
Main Results:
- Successful elimination of clinical cases of shigellosis within the primate colony.
- Absence of further Shigella isolations following the intervention, indicating complete eradication.
Conclusions:
- The integrated approach effectively controlled and eradicated shigellosis in the studied primate colony.
- Improvements in diagnostics, treatment, and management are critical for controlling infectious diseases in research animals.