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Adverse skin reaction from vitamin K1
The British Journal of Dermatology
|December 1, 1976
Summary
Vitamin K1 injections can cause skin reactions like red, tender plaques in patients with liver disease. These reactions, though temporary, may be linked to underlying liver conditions and drug administration.
Area of Science:
- Dermatology
- Hepatology
Background:
- Intramuscular injections of vitamin K1 are common for various medical conditions.
- Cutaneous reactions to medications can occur, but specific responses to vitamin K1 injections are rare.
Observation:
- Two patients presented with erythematous, tender, indurated plaques at vitamin K1 injection sites.
- One patient experienced a similar reaction upon receiving a test dose.
- Both patients had underlying liver disease.
Findings:
- The observed skin lesions, characterized by red, indurated plaques, resolved within 4 to 14 days.
- Previous literature reports similar cutaneous reactions.
- Sclerodermatous changes at injection sites were noted in some patients within two years.
Implications:
- The development of these cutaneous reactions appears to be associated with liver disease and the administration of various drugs.
- Further research is warranted to understand the specific mechanisms linking liver disease, drug administration, and these unique dermatological responses.