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Factor V in an industrial population.

M Brozović, R Chakrabarti, Y Stirling

    British Journal of Haematology
    |August 1, 1976
    PubMed
    Summary
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    Factor-V levels, crucial for blood clotting, increase with age and are higher with difficult blood draws. These levels are unaffected by gender, race, oral contraceptives, or menopause.

    Area of Science:

    • Hematology
    • Clinical Chemistry
    • Coagulation Science

    Background:

    • Factor-V is a critical protein in the blood coagulation cascade.
    • Understanding Factor-V levels is important for assessing hemostasis and thrombosis risk.

    Purpose of the Study:

    • To measure Factor-V levels in a diverse adult population.
    • To investigate factors influencing Factor-V levels, including venipuncture difficulty, age, sex, race, oral contraceptive use, menopause, blood group, and secretor status.

    Main Methods:

    • Automated one-stage assay using a standardized thromboplastin batch.
    • Analysis of Factor-V levels in 626 men and 307 women from North West London.
    • Statistical analysis to identify significant correlations with demographic and physiological factors.

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    Main Results:

    • Factor-V levels were significantly higher (mean ~130%) with difficult venipuncture compared to satisfactory draws (mean ~117%).
    • Factor-V levels showed a significant positive correlation with age, increasing by approximately 0.6% per annum.
    • No significant differences in Factor-V levels were observed based on sex, race, oral contraceptive use, menopause, blood group, or secretor status.

    Conclusions:

    • Venipuncture difficulty and increasing age are significant determinants of Factor-V levels.
    • Factor-V levels are robust across various demographic and physiological factors, suggesting a stable baseline in the studied population.