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Topical pefloxacin in bacterial keratitis
R B Vajpayee1, N Sharma, B Verma
1Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.
International Ophthalmology
|March 25, 1999
Summary
Topical pefloxacin 0.3% drops effectively treated bacterial keratitis in a clinical trial. The antibiotic demonstrated high resolution rates for bacterial corneal ulcers, proving its efficacy as a standalone treatment.
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Background:
- Bacterial keratitis is a significant cause of visual impairment.
- Identifying effective monotherapy for bacterial corneal ulcers is crucial for treatment protocols.
Purpose of the Study:
- To assess the clinical efficacy and safety of topical pefloxacin 0.3% drops.
- To determine pefloxacin's effectiveness as the sole antibiotic for bacterial corneal ulcers.
Main Methods:
- A prospective, open-label clinical trial was conducted.
- 32 Gram's smear-positive bacterial corneal ulcer cases were treated with topical pefloxacin 0.3% drops.
- Patients received supportive therapies including cycloplegic, vitamin, and antiglaucoma treatments.
Main Results:
- Pefloxacin achieved a 96.9% resolution rate for bacterial corneal ulcers.
- Staphylococcus aureus and coagulase-negative Staphylococci were the most common pathogens.
- Good visual acuity (20/200 or better) was achieved in 65.6% of patients post-treatment.
Conclusions:
- Topical pefloxacin 0.3% is an effective single-agent antibiotic for bacterial keratitis.
- Pefloxacin offers a safe and efficient treatment option for bacterial corneal ulcers.