A note on power approximations for the transmission/disequilibrium test
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1Institute for Medical Statistics, University of Bonn, 53105 Bonn, Germany. knapp@imsdd.meb.uni-bonn.de
Abstract:
The transmission/disequilibrium test (TDT) is a popular method for detection of the genetic basis of a disease. Investigators planning such studies require computation of sample size and power, allowing for a general genetic model. Here, a rigorous method is presented for obtaining the power approximations of the TDT for samples consisting of families with either a single affected child or affected sib pairs. Power calculations based on simulation show that these approximations are quite precise. By this method, it is also shown that a previously published power approximation of the TDT is erroneous.
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