Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transfusional transmitted viruses in pregnancy.

A Eleftheriou1, G Kalakoutis, N Pavlides

  • 1Virus Reference Laboratory, Arch. Makarios III Hospital, Nicosia, Cyprus.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|March 26, 1999
PubMed
Summary

Transfusion-transmitted infections, particularly hepatitis B, C, and HIV, pose risks for thalassaemia patients. Monitoring these viral infections is crucial for pregnant thalassaemic individuals and their newborns, especially for Hepatitis C transmission.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optical coherence tomography represents a sensitive and reliable tool for routine monitoring of idiopathic intracranial hypertension with and without papilledema.

European journal of neurology·2018
Same author

Long-term changes in the structure of benthic communities: Revisiting a sampling transect in Crete after 24 years.

Marine environmental research·2018
Same author

Abstracts from Hydrocephalus 2016.

Fluids and barriers of the CNS·2017
Same author

Bilateral hydronephrosis with urinary tract infection in a Campbell's hamster (Phodopus campbelli).

The Journal of small animal practice·2015
Same author

International network on endocrine complications in thalassaemia (I-CET): an opportunity to grow.

Georgian medical news·2012
Same author

Preimplantation diagnosis and HLA typing for haemoglobin disorders.

Reproductive biomedicine online·2005

Area of Science:

  • Hematology
  • Infectious Diseases
  • Virology

Background:

  • Blood transfusions can transmit infectious agents, with transfusion-associated hepatitis (TAH) being a historically significant complication.
  • Thalassaemia major patients exhibit increased susceptibility to blood-transmitted viruses like Hepatitis B (HBV), Hepatitis C (HCV), Human Immunodeficiency Virus (HIV), Cytomegalovirus (CMV), and Parvovirus B19 (HPV B-19).
  • Monitoring transfusion-transmitted infections (TTIs) is a critical component of clinical management for thalassaemia patients.

Purpose of the Study:

  • To highlight the importance of monitoring blood-transmitted viral infections in thalassaemia patients, particularly during pregnancy.
  • To emphasize the need for understanding vertical transmission of viruses like HCV from pregnant thalassaemic mothers to their foetuses/newborns.
  • To identify gaps in knowledge regarding HCV vertical transmission, clinical outcomes, and the role of other TTIs like CMV and HPV B-19.

Related Experiment Videos

Main Methods:

  • Review of existing literature on transfusion-transmitted infections in thalassaemia.
  • Analysis of clinical management protocols for pregnant thalassaemic patients.
  • Identification of prevalent viruses (HBV, HCV, HIV, CMV, HPV B-19) and transmission routes.

Main Results:

  • Preventative measures have reduced HBV and HIV transmission, but challenges remain for HCV.
  • Hepatitis (B and C) and HIV are frequently encountered in pregnant thalassaemic patients.
  • CMV and HPV B-19 infections are common in thalassaemic patients, with potential for reactivation and co-infection.

Conclusions:

  • Vigilant monitoring of TTIs is essential for thalassaemia patients, especially pregnant women, to protect both mother and child.
  • Further research is needed to clarify the mechanisms, frequency, and outcomes of HCV vertical transmission.
  • The implications of CMV and HPV B-19 reactivation and vertical transmission in thalassaemic pregnancies require further investigation.