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Substituted furans as inhibitors of the PDE4 enzyme
H Perrier1, C Bayly, F Laliberté
1Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Québec, Canada.
Bioorganic & Medicinal Chemistry Letters
|March 26, 1999
Abstract:
The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emetic threshold with known PDE4 inhibitors is presented.
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