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Synthesis and biological evaluation of 1alpha,24-dihydroxy-25-nitrovitamin D3

J Oshida¹, M Okamoto, S Ishizuka

¹Iwakuni Pharmaceutical Factory, Teijin, Ltd., Iwakuni, Yamaguchi, Japan.

Bioorganic & Medicinal Chemistry Letters

|March 26, 1999

Abstract:

1Alpha,24(R)Dihydroxy-25-nitrovitamin D3 1 and 1alpha,24(S)-dihydroxy-25-nitrovitamin D3 2 were synthesized using the palladium-catalyzed alkylative enyne cyclization reaction. Their biological properties were studied based on VDR binding affinity and HL-60 cell differentiation activity.

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