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Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives
K Shinozaki1, H Sato, T Iwakuma
1Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Ohsatogun, Saitama, Japan.
Bioorganic & Medicinal Chemistry Letters
|March 26, 1999
Abstract:
A new series of indane derivatives were prepared and evaluated for their thromboxane A2 (TXA2, 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a potent TXA2 antagonist in oral administration.