Evolution of acute cytomegalovirus gastritis to chronic gastrointestinal dysmotility in a nonimmunocompromised adult
Summary
This summary is machine-generated.Cytomegalovirus (CMV) infection can cause chronic gastrointestinal dysmotility in healthy individuals. This condition may persist long after the viral infection is cleared, impacting digestive system function.
Area Of Science
- Gastroenterology
- Infectious Diseases
- Virology
Background
- Cytomegalovirus (CMV) is a common virus that can cause various health issues.
- Gastrointestinal dysmotility refers to impaired movement of the digestive tract.
- This case explores the link between CMV infection and chronic gastrointestinal issues in an immunocompetent patient.
Observation
- A 30-year-old non-immunocompromised woman presented with chronic gastrointestinal dysmotility.
- Acute CMV infection was confirmed by IgM antibodies, with persistent CMV in gastrointestinal biopsies for 2.5 years.
- Gastrointestinal dysmotility was objectively confirmed through gastric emptying studies, small intestinal manometry, and electrogastrography.
Findings
- The patient experienced nausea, vomiting, abdominal pain, and early satiety.
- Symptoms temporarily resolved with leuprolide acetate treatment but recurred upon discontinuation.
- Gastrointestinal symptoms persisted even after CMV eradication from the GI tract with ganciclovir.
Implications
- Acute CMV infection can induce long-lasting gastrointestinal dysmotility in immunocompetent individuals.
- This suggests a potential mechanism where CMV infection disrupts normal gastrointestinal motor function.
- The findings highlight the importance of considering viral infections in unexplained chronic gastrointestinal motility disorders.
View abstract on PubMed