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Related Experiment Videos

Motor function in aging Great Lakes fisheaters.

S L Schantz1, J C Gardiner, D M Gasior

  • 1College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. schantz@uiuc.edu

Environmental Research
|March 27, 1999
PubMed
Summary

Polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) exposure from Great Lakes fish did not significantly impair fine motor skills in older adults. Age and gender were more influential factors on neurobehavioral outcomes than contaminant levels.

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Area of Science:

  • Environmental Health
  • Neurotoxicology
  • Gerontology

Background:

  • Great Lakes fish consumption is a known exposure route for environmental contaminants like PCBs and DDE.
  • Previous studies linked contaminant exposure to impaired neuropsychological functioning in children.
  • Neurological effects of these contaminants in adults, particularly older adults, remain less understood.

Purpose of the Study:

  • To evaluate the association between polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) exposure from Great Lakes fish and fine motor function in older adults.
  • To assess the impact of long-term exposure to these persistent organic pollutants on neurobehavioral outcomes in a cohort of Michigan residents.

Main Methods:

  • Cross-sectional analysis of 50-90-year-old Michigan residents, categorizing participants into high, intermediate, and low exposure groups based on serum PCB/DDE levels.

Related Experiment Videos

  • Utilized the Static Motor Steadiness Test (SMST) and Grooved Pegboard Test (GPT) to measure fine motor function.
  • Controlled for age and gender in multiple regression models to determine the significance of contaminant exposure on motor function.

    • Main Results:

    • Unadjusted analyses showed a significant association between high PCB/DDE exposure and poorer performance on the Grooved Pegboard Test (GPT).
    • In adjusted models, age and gender were significant predictors of GPT scores, while PCB/DDE exposure was not.
    • Performance on the Static Motor Steadiness Test (SMST) showed a marginal association with PCB/DDE exposure for the dominant hand, with scores improving slightly as exposure increased.

    Conclusions:

    • PCB/DDE exposure from consuming Great Lakes fish did not demonstrate a significant negative impact on fine motor skills or hand steadiness in this cohort of older adults.
    • Age and gender appear to be more critical determinants of fine motor function in older populations than the studied levels of PCB/DDE exposure.
    • Further research may be warranted to explore subtle long-term neurological effects or different exposure scenarios.