Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Viruses and human cancer.

W Eckhart1

  • 1Cancer Center, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Science Progress
|March 27, 1999
PubMed
Summary

Human cancer viruses, including human papillomavirus and hepatitis B virus, cause 10-20% of global cancers. These viruses disrupt cell controls, leading to malignancy and cancer development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of focal adhesion kinase in MAP kinase activation by insulin-like growth factor-I or insulin.

FEBS letters·1999
Same author

A role for insulin-like growth factor-I in the regulation of Schwann cell survival.

The Journal of neuroscience : the official journal of the Society for Neuroscience·1999
Same author

C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor.

The Journal of biological chemistry·1999
Same author

Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research·1998
Same author

Tyrosine phosphorylation of connexin 43 by v-Src is mediated by SH2 and SH3 domain interactions.

The Journal of biological chemistry·1997
Same author

Regulation of connexin43 function by activated tyrosine protein kinases.

Journal of bioenergetics and biomembranes·1996

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Viruses are responsible for a significant portion of human cancers globally (10-20%).
  • Key human cancer viruses include human papillomavirus (HPV), hepatitis B virus (HBV), Epstein-Barr virus (EBV), human T cell lymphotropic virus (HTLV), and Kaposi's sarcoma-associated herpesvirus (KSHV).

Purpose of the Study:

  • To elucidate the mechanisms by which specific viruses induce cancer in humans.
  • To understand how viral replication and cellular transformation contribute to oncogenesis.

Main Methods:

  • Review and synthesis of existing research on virus-associated cancers.
  • Analysis of viral interactions with host cell machinery.

Main Results:

  • Cancer viruses hijack cellular processes to ensure their survival and proliferation.
  • Viral activity interferes with normal cellular regulatory mechanisms, promoting uncontrolled growth and genetic instability.
  • This interference ultimately leads to the development of malignant tumors.

Conclusions:

  • Viruses play a critical role in human carcinogenesis by altering cellular functions.
  • Ongoing research into virus replication and neoplastic transformation is key to understanding and combating virus-induced cancers.

Related Experiment Videos