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Cardiovascular consequences of the aging process.

S P Schulman1

  • 1Coronary Care Unit, John Hopkins Hospital, Baltimore, Maryland, USA.

Cardiology Clinics
|March 27, 1999
PubMed
Summary
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Aging affects the cardiovascular system, causing impaired diastolic filling, reduced adrenergic response, and increased arterial stiffness. These changes impact cardiovascular disease in older adults.

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Physiology

Background:

  • Studying normal aging of the cardiovascular system presents challenges, particularly due to the high prevalence of cardiovascular disease in the elderly.
  • Age-associated cardiovascular changes are common, affecting both animal models and healthy human populations.

Purpose of the Study:

  • To outline key age-associated changes in the cardiovascular system.
  • To discuss the influence of lifestyle on these changes.
  • To highlight how these changes affect cardiovascular disease presentation and treatment in older adults.

Main Methods:

  • Review of existing literature on cardiovascular aging in animal models and humans.
  • Identification of three primary age-associated cardiovascular changes.

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  • Consideration of lifestyle factors and their impact.

    • Main Results:

    • Three significant age-associated cardiovascular changes identified: impaired left ventricular diastolic filling, reduced adrenergic responsiveness to catecholamines, and increased arterial stiffness.
    • Sedentary lifestyles are suggested as a contributing factor to these age-related cardiovascular alterations.
    • These physiological changes influence how cardiovascular diseases manifest and respond to treatments in the elderly.

    Conclusions:

    • Cardiovascular aging is characterized by specific physiological changes that impact overall cardiac function.
    • Lifestyle modifications may play a role in mitigating age-associated cardiovascular decline.
    • Understanding these age-related cardiovascular changes is crucial for effective management of cardiovascular disease in older populations.