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[Frontal lobe dementia. Clinical-pathologic case reports].

C Zachhuber1, F Leblhuber, C Bancher

  • 1Abteilung für Neurologisch-Psychiatrische Gerontologie, Landesnervenklinik Wagner-Jauregg, Linz.

Fortschritte Der Neurologie-Psychiatrie
|March 27, 1999
PubMed
Summary
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Frontal lobe dementia (FLD) presents with personality changes and speech decline. This study highlights FLD

Area of Science:

  • Neurology
  • Gerontology

Background:

  • Frontal lobe dementia (FLD) is a neurodegenerative disorder.
  • Characterized by personality shifts and progressive speech impairment leading to mutism.

Observation:

  • FLD can co-occur with other neurological syndromes like parkinsonism, Klüver-Bucy syndrome, and motor neuron disease (MND).
  • FLD with MND has a rapid, fatal course within approximately three years.
  • Clinical diagnosis is aided by SPECT, CT, and MRI.
  • Nine FLD cases were diagnosed between 1988-1997, with most showing presenile onset.

Findings:

  • Six of nine patients presented with FLD + MND.
  • Parkinsonism and partial Klüver-Bucy syndrome were observed in five cases each.
  • Histopathological studies suggest an increasing incidence of FLD.

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Implications:

  • FLD should be considered in the differential diagnosis of presenile dementia syndromes.
  • Understanding FLD's varied presentations is crucial for accurate diagnosis and management.
  • Further research into FLD's increasing incidence and pathological mechanisms is warranted.