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Murine protein kinase CK2: gene and oncogene

X Xu1, E Landesman-Bollag, P L Channavajhala

  • 1Department of Medicine, Boston University Medical Center, MA 02118, USA.

Molecular and Cellular Biochemistry
|March 27, 1999
PubMed

Insights

Protein kinase CK2 (casein kinase II) is an oncogene that drives lymphoma development. This study shows CK2 cooperates with p53 loss to promote cancer, furthering our understanding of its pathological role.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Protein kinase CK2 (casein kinase II) is a serine-threonine kinase regulating cell cycle processes.
  • Elevated CK2 activity is observed in various human tumors, suggesting its oncogenic potential.

Purpose of the Study:

  • To investigate the role of dysregulated Protein kinase CK2 (CK2) in cancer development.
  • To explore the cooperative mechanisms of CK2 in oncogenesis, particularly with tumor suppressor gene p53 loss.

Main Methods:

  • Utilized a transgenic mouse model to study CK2's role in lymphoma induction.
  • Investigated the cooperation between CK2 and other oncogenes (myc, tal-1) and the tumor suppressor gene p53.

Main Results:

  • Demonstrated that dysregulated CK2 expression can induce lymphoma in mice, fulfilling the criteria for an oncogene.
  • Showed that CK2 cooperates with the loss of the tumor suppressor gene p53 in cancer development.

Conclusions:

  • CK2 acts as an oncogene, contributing to cancer in a dominant manner.
  • Further research involves cloning murine CK2alpha' cDNA and gene for generating transgenic and knockout mice to analyze regulatory elements.

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