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Molecular characterization of the tight junction protein ZO-1 in MDCK cells

L González-Mariscal1, S Islas, R G Contreras

  • 1Department of Physiology, Biophysics, and Neuroscience, Center for Research and Advanced Studies (CINVESTAV), México, D.F., 07000, México.

Experimental Cell Research
|March 30, 1999
PubMed

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Overview of Cell-Matrix Interactions

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Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
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Tight Junctions

Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
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