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Immunohistochemical examination of NOS and SOD in nasal mucosa
T Sawada1, T Nishimura, M Saki
1Department of Otolaryngology, Fujita Health University, Second Affiliated Hospital Nagoya, Aichi, Japan.
Acta Oto-Laryngologica. Supplementum
|March 30, 1999
Abstract:
An immunohistochemical examination was performed to detect the localization of neural-type nitric oxide synthase (nNOS), endothelial-type NOS (eNOS) and inducible-type NOS (iNOS) in the human and mouse nasal mucosa. nNOS-immunoreactive nerve fibers were found in the subepithelial layer and around the seromucous glands of mice. In these fibers, immunodouble staining revealed co-localization of nNOS and superoxide dismutase (SOD). In the human nasal mucosa of normal subjects, strong eNOS immunoreactivity and weak iNOS immunoreactivity were found in the columnar epithelium.