Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Standard gentamicin dosage regimen in neonates.

T M Langlass1, T R Mickle

  • 1Owen Healthcare, Inc., McAllen Medical Center, TX 78503, USA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|March 30, 1999
PubMed
Summary

A new gentamicin dosage of 3.5 mg/kg every 24 hours significantly reduced high trough concentrations in neonates. This optimized gentamicin regimen improved safety and efficacy for neonatal intensive care unit patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of recombinant fowl poxvirus vaccine in protecting chickens against a highly pathogenic Mexican-origin H5N2 avian influenza virus.

Avian diseases·1998
Same author

Efficacy of a recombinant fowl pox-based Newcastle disease virus vaccine candidate against velogenic and respiratory challenge.

Avian diseases·1996
Same author

Metformin: a biguanide.

The Diabetes educator·1995
Same author

Evaluation of pharmacists' practice in patient education when dispensing a metered-dose inhaler.

DICP : the annals of pharmacotherapy·1990
Same author

Review of diclofenac and evaluation of its place in therapy as a nonsteroidal antiinflammatory agent.

Drug intelligence & clinical pharmacy·1988
Same author

Avoiding medication errors with transdermal nitroglycerin products.

American journal of hospital pharmacy·1986

Area of Science:

  • Neonatal Pharmacology
  • Pediatric Infectious Diseases
  • Clinical Pharmacy

Background:

  • Previous gentamicin dosing regimens in neonates with gestational age (GA) of ≥30 weeks resulted in high trough serum concentrations (>2 microg/mL).
  • These high trough levels indicate potential for sub-therapeutic efficacy or increased toxicity.

Purpose of the Study:

  • To evaluate a revised gentamicin dosage protocol of 3.5 mg/kg every 24 hours in neonates with GA ≥30 weeks.
  • To determine if the new regimen reduces the frequency of high trough gentamicin concentrations compared to previous practices.

Main Methods:

  • A baseline group received standard gentamicin (2.5 mg/kg IV every 12, 18, or 24 hours).
  • A protocol group received the revised gentamicin dose (3.5 mg/kg IV every 24 hours).

Related Experiment Videos

  • Trough and peak gentamicin concentrations were measured, and renal impairment was monitored.

    • Main Results:

    • The protocol group showed significantly lower trough gentamicin concentrations (4% vs. 33% high troughs) compared to the baseline group.
    • The revised regimen resulted in significantly higher peak gentamicin concentrations.
    • No patients in either group developed renal impairment.

    Conclusions:

    • A gentamicin dosage of 3.5 mg/kg every 24 hours is effective in reducing high trough concentrations in neonates (GA ≥30 weeks).
    • This optimized regimen achieves higher peak levels while maintaining safety, with no observed renal toxicity.
    • The new protocol offers an improved approach to gentamicin dosing in this neonatal population.