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Related Experiment Videos

Prolactin levels during the menstrual cycle.

P Franchimont, C Dourcy, J J Legros

    Clinical Endocrinology
    |November 1, 1976
    PubMed
    Summary
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    Prolactin levels fluctuate during the menstrual cycle, showing higher concentrations in the ovulatory and luteal phases. A direct relationship exists between estradiol and prolactin, but not with FSH, LH, or progesterone.

    Area of Science:

    • Reproductive Endocrinology
    • Hormonal Regulation of the Menstrual Cycle

    Background:

    • The menstrual cycle involves complex hormonal interplay, including pituitary gonadotropins (FSH, LH), ovarian steroids (estradiol, progesterone), and prolactin.
    • Understanding the dynamic changes of these hormones is crucial for reproductive health assessment.

    Purpose of the Study:

    • To investigate the daily fluctuations of prolactin, FSH, LH, estradiol, and progesterone throughout ovulatory menstrual cycles.
    • To determine the relationship between prolactin levels and other key reproductive hormones during different cycle phases.

    Main Methods:

    • Daily measurement of serum prolactin, FSH, LH, estradiol, and progesterone.
    • Analysis conducted over fourteen documented ovulatory cycles.

    Main Results:

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    • FSH, LH, estradiol, and progesterone exhibited classical ovulatory cycle patterns.
    • Prolactin levels showed non-systematic variations, with peaks often occurring during the ovulatory or luteal phases.
    • Mean prolactin levels were significantly elevated during the ovulatory and luteal phases compared to the follicular phase.

    Conclusions:

    • Prolactin levels exhibit significant increases during the ovulatory and luteal phases of the menstrual cycle.
    • A direct correlation was observed between estradiol and prolactin levels.
    • No significant correlation was found between prolactin and FSH, LH, or progesterone levels.