Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recurrent inhibition in humans.

R Katz1, E Pierrot-Deseilligny

  • 1Laboratoire de Neurophysiologie Clinique Rééducation, Hôpital de la Salpétrière, Paris, France.

Progress in Neurobiology
|March 30, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perception of non-voluntary brief contractions in normal subjects and in a deafferented patient.

Experimental brain research·2004
Same author

Group II excitations from plantar foot muscles to human leg and thigh motoneurones.

Experimental brain research·2004
Same author

Low fluence.

Advances in space research : the official journal of the Committee on Space Research (COSPAR)·2003
Same author

Evidence for recurrent inhibition of reciprocal inhibition from soleus to tibialis anterior in man.

Experimental brain research·2003
Same author

Complete solo laparoscopic radical prostatectomy: initial experience.

Urology·2003
Same author

Chemical bonds broken in latent tracks of light ions in plastic track detectors.

Radiation protection dosimetry·2002
Same journal

Deletion of Fbxo25 causes excessive repetitive behavior, impaired recognition memory, reduced dendritic complexity, and aberrant protein expression in mice.

Progress in neurobiology·2026
Same journal

Neuropsychiatric Disease Mechanisms and Interventions. from 22q11.2 Deletion Syndrome Experimental Studies.

Progress in neurobiology·2026
Same journal

REM sleep as a dummy-model of the world: A theoretical framework.

Progress in neurobiology·2026
Same journal

CA3 transiently modulates spatial representation in CA1.

Progress in neurobiology·2026
Same journal

Love, death, and oxytocin: In memory of Larry Young.

Progress in neurobiology·2026
Same journal

Assessing peripheral oxytocin and cortisol levels and epigenetic variations of oxytocin receptor and glucocorticoid receptor genes in school-aged preterm-born children.

Progress in neurobiology·2026
See all related articles

Recurrent inhibition (RI) in humans, mediated by Renshaw cells (RCs), is crucial for motor control. While generally present, its regulation by descending pathways is impaired in spasticity, affecting muscle force and movement.

Area of Science:

  • Neuroscience
  • Motor Control
  • Human Physiology

Background:

  • Recurrent inhibition (RI) is a fundamental neural mechanism involving Renshaw cells (RCs).
  • Understanding RI in humans is vital for comprehending motor control and neurological disorders.
  • Previous studies established RI in animal models, necessitating human-specific investigations.

Purpose of the Study:

  • To characterize recurrent inhibition (RI) in human motoneurones (MNs).
  • To investigate the control of RI by descending pathways during voluntary contractions.
  • To explore the role of RI dysfunction in spasticity.

Main Methods:

  • Utilized conditioning reflex discharges to evoke and measure RI in human limb MNs.
  • Examined RI during various voluntary and postural contractions (homonymous, synergistic, antagonistic).

Related Experiment Videos

  • Assessed changes in RI transmission modulated by descending tracts and muscle contraction strength.

    • Main Results:

    • Confirmed homonymous RI in human limb motor nuclei (excluding digits) and heteronymous RI distribution patterns.
    • Identified significant inter-species differences in heteronymous RI distribution between humans and cats.
    • Demonstrated powerful descending control over RC activation, influencing RI magnitude during contractions.
    • Observed decreased RI at rest in progressive paraparesis, linked to spasticity.
    • Found disturbed RC control during voluntary movement in spasticity patients.

    Conclusions:

    • Human RI shares similarities with animal models but exhibits distinct inter-species variations.
    • Descending pathways exert significant control over RCs, potentially regulating muscle force.
    • Dysfunctional RC control contributes to motor disability in spasticity, even with normal resting RI.