Remangilones A-C, new cytotoxic triterpenes from Physena madagascariensis

¹Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.

|March 30, 1999

Abstract:

Three new 24,28-dinorolean-3-one derivatives, the remangilones A-C (1-3), were isolated from the dried leaves of Physena madagascariensis using a human mammary carcinoma cell line to guide the isolation. The structures of 1-3 were deduced primarily from NMR studies. Compounds 1 and 3, remangilones A and C, respectively, were found to be cytotoxic against two human breast cancer cell lines and induced apoptosis at concentrations of 2.3 microM.

Related Concept Videos

Articles linked to this work by shared authors, journal, and citation graph.

First Measurement of the Decay-Time-Integrated CP Asymmetry in B_{s}^{0}→D_{s}^{-}π^{+} Decays.

Physical review letters·2026

Study of Nuclear Effects on Charm Production in Light-Ion Collisions.

Physical review letters·2026

First Evidence of the Decay B^{+}→π^{+}e^{+}e^{-}.

Physical review letters·2026

CP Violation Analysis of Local and Nonlocal Amplitudes in the B[over ¯]^{0}→K[over ¯]^{*0}μ^{+}μ^{-} Decay.

Physical review letters·2026

Search for the Lepton-Flavor Violating Decays B^{+}→π^{+}μ^{±}e^{∓}.

Physical review letters·2026

Test of Lepton Flavor Universality with B^{0}→K^{*0}ℓ^{+}ℓ^{-} Decays at Large Dilepton Invariant Mass.

Physical review letters·2026

See all related articles

Related Experiment Videos

Remangilones A-C, new cytotoxic triterpenes from Physena madagascariensis

Related Concept Videos

First Measurement of the Decay-Time-Integrated CP Asymmetry in B_{s}^{0}→D_{s}^{-}π^{+} Decays.

Study of Nuclear Effects on Charm Production in Light-Ion Collisions.

First Evidence of the Decay B^{+}→π^{+}e^{+}e^{-}.

CP Violation Analysis of Local and Nonlocal Amplitudes in the B[over ¯]^{0}→K[over ¯]^{*0}μ^{+}μ^{-} Decay.

Search for the Lepton-Flavor Violating Decays B^{+}→π^{+}μ^{±}e^{∓}.

Test of Lepton Flavor Universality with B^{0}→K^{*0}ℓ^{+}ℓ^{-} Decays at Large Dilepton Invariant Mass.

Characterization of Dapalides D and E and Genomic Comparison of the Two Co-Occurring Dapalide-Producing Dapis spp.

Purity of Natural Products: Meta Analysis and Current Status─AnaPurNa 2.0.

Genome Mining of the Biocontrol Fungus Trichoderma afroharzianum T22 Led to the Discovery of Dehydrobutyrine-Containing Lipopeptides.

Evaluation of the Alkaloid Secretions within the Millipede Brachycybe and Their Pheromone Properties.

Diacarnusins A-F, nor-Terpene Endoperoxides of the Red Sea Sponge Diacarnus erythraeanus.

Regulator-Guided Strain Prioritization and Genome Engineering Uncovers Concanamycin Analogs.

Synthesis, Biological Evaluation, and Biodistribution of Xinyne, a Novel Quinazoline-carbazole N-methylamine Anticancer Agent Used in Mice Xenograft Models.

Development of Covalent Inhibitors of Chikungunya Virus nsP2 Cysteine Protease Enabled by Direct-to-Biology Synthesis and Screening.

Discovery and Crystallographic Study of Water-Soluble Quaternary Ammonium-Based PD-1/PD-L1 Inhibitors with Anti-Angiogenic Activity.

Optimization of a Series of Novel 1H-Pyrrolo[3,2-c]pyridine-Based USP1 Inhibitors with Potent In Vivo Antitumor Activity.

Structure-Based Design and Optimization of Onradivir-Derived PB2 Inhibitors for the Treatment of Influenza A.

Ion-Channel Activity of Characteristic Alkaloids From Uncaria rhynchophylla.

Related Experiment Videos

Remangilones A-C, new cytotoxic triterpenes from Physena madagascariensis

Abstract:

Related Concept Videos

Related Articles