Remangilones A-C, new cytotoxic triterpenes from Physena madagascariensis

¹Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.

|March 30, 1999

Abstract:

Three new 24,28-dinorolean-3-one derivatives, the remangilones A-C (1-3), were isolated from the dried leaves of Physena madagascariensis using a human mammary carcinoma cell line to guide the isolation. The structures of 1-3 were deduced primarily from NMR studies. Compounds 1 and 3, remangilones A and C, respectively, were found to be cytotoxic against two human breast cancer cell lines and induced apoptosis at concentrations of 2.3 microM.

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