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[Anxiety-inducing and -inhibiting agents: differential effect of pentagastrins on the white rat behavior]
R A Danilova1, I M Fedorova, O I Rud'ko
1Moscow State University, Vorobyevy Gory, Russia.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|March 31, 1999
Abstract:
Parenteral administration of des-BOC-Pentagastrin induced the anxiety and fear manifestations, depressing also explorative behaviour in open field experiments in rats. Intranasal administration evoked similar effects, whereas pentagastrin reduced the anxiety level, increasing explorative behaviour. Pentagastrin and des-BOC-Pentagastrin displayed antagonism at the receptor level.