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Related Experiment Videos

Virulence evolution in a virus obeys a trade-off.

S L Messenger1, I J Molineux, J J Bull

  • 1Department of Zoology, University of Texas, Austin 78712, USA.

Proceedings. Biological Sciences
|March 31, 1999
PubMed
Summary

This study on virus virulence shows that higher rates of infectious transmission lead to increased virulence and virus production. These findings support the trade-off model for virulence evolution in pathogens.

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EVOLUTION OF PHENOTYPIC VARIANCE.

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Area of Science:

  • Evolutionary Biology
  • Microbiology
  • Virology

Background:

  • The evolution of pathogen virulence is a complex process influenced by transmission modes.
  • Understanding the factors driving virulence evolution is crucial for predicting disease dynamics.

Purpose of the Study:

  • To investigate the evolution of virulence in bacteriophage f1 under alternating vertical and horizontal transmission.
  • To test the trade-off model of virulence evolution.

Main Methods:

  • Bacteriophage f1 was used, experiencing alternating vertical (host to progeny) and horizontal (new host infection) transmission.
  • Transmission intervals varied in duration, altering the selection pressure against virulence.
  • Viral lines were monitored for changes in virulence and virus production.

Main Results:

  • Viral lines with a higher enforced rate of infectious transmission evolved increased virulence.
  • Higher transmission rates also correlated with higher rates of virus production.
  • The duration of vertical transmission influenced the intensity of selection against virulence.

Conclusions:

  • Results support the trade-off model, suggesting virulence evolves in response to transmission strategies.
  • Transmission mode and duration significantly impact the evolutionary trajectory of pathogen virulence.

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