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Antimicrobial resistance in enterococci.

C H Pai1, M N Kim

  • 1Department of Clinical Pathology, University of Ulsan, College of Medicine, Seoul, Korea. chpai@www.amc.seoul.kr

Yonsei Medical Journal
|March 31, 1999
PubMed
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Enterococci are difficult-to-treat nosocomial pathogens causing antimicrobial resistance. This review examines their epidemiology, resistance mechanisms, and detection for aminoglycosides and glycopeptides.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Enterococci are significant nosocomial pathogens.
  • They possess inherent resistance to many antimicrobials.
  • Enterococci readily acquire new resistance mechanisms.

Purpose of the Study:

  • To review the epidemiology of enterococcal infections.
  • To examine mechanisms of antimicrobial resistance in enterococci.
  • To discuss laboratory detection of enterococcal resistance.

Main Methods:

  • Literature review focusing on enterococcal resistance.
  • Analysis of epidemiological data.
  • Examination of molecular mechanisms of resistance.

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Main Results:

  • Enterococci exhibit increasing resistance to aminoglycosides and glycopeptides.
  • Mechanisms include beta-lactamase production and high-level aminoglycoside resistance.
  • Glycopeptide resistance is a growing concern.

Conclusions:

  • Enterococci present a major challenge in healthcare settings.
  • Understanding resistance is crucial for effective treatment and control.
  • Further research on detection and management is needed.