Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute autoimmune thrombocytopenia.

A H Sutor1, G Gaedicke

  • 1Section Haematology and Haemostaseology Universitäts-Kinderklinik, Freiburg, Germany.

Bailliere'S Clinical Haematology
|March 31, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The importance of the patient voice in vaccination and vaccine safety-are we listening?

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016
Same author

Simultaneous, phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody enhances antiangiogenic effects in vivo.

Klinische Padiatrie·2006
Same author

Response to intravenous immunoglobulin G in an infant with immunoglobulin A-associated autoimmune haemolytic anaemia.

Vox sanguinis·2004
Same author

Vaccination with minigenes encoding for novel 'self' antigens are effective in DNA-vaccination against neuroblastoma.

Cancer letters·2003
Same author

Neuroblastoma directed therapy by a rational prodrug design of etoposide as a substrate for tyrosine hydroxylase.

Cancer letters·2003
Same author

Rationally designed hydrolytically activated etoposide prodrugs, a novel strategy for the treatment of neuroblastoma.

Cancer letters·2003

Childhood acute autoimmune thrombocytopenia, a benign bleeding disorder, involves transient platelet destruction. Diagnosis relies on history, physical exam, and blood counts, with bone marrow biopsy reserved for uncertain cases.

Area of Science:

  • Pediatrics
  • Hematology
  • Immunology

Background:

  • Childhood acute autoimmune thrombocytopenia is a bleeding disorder in healthy children.
  • Characterized by transient platelet destruction, it typically presents with skin purpura and minor bleeds.
  • Diagnosis involves medical history, physical examination, and complete blood count with peripheral blood smear analysis.

Purpose of the Study:

  • To outline diagnostic criteria for childhood acute autoimmune thrombocytopenia.
  • To discuss the role of bone marrow examination and risk stratification.
  • To review the mechanisms and efficacy of treatments like immunoglobulins and glucocorticoids.

Main Methods:

  • Review of diagnostic indicators including infections, immunizations, and physical signs.

Related Experiment Videos

  • Analysis of complete blood count and peripheral blood smear for platelet assessment.
  • Consideration of bone marrow examination for diagnostic uncertainty and treatment planning.

    • Main Results:

    • A definitive platelet count threshold for risk stratification in immune thrombocytopenia (ITP) is currently unknown.
    • Immunoglobulins and glucocorticoids may increase platelet counts by inhibiting the monocyte-macrophage system.
    • The clinical impact of treatment-induced platelet count increases on bleeding and mortality remains unclear.

    Conclusions:

    • Diagnosis of childhood acute autoimmune thrombocytopenia is primarily clinical and hematological.
    • The benefits versus risks of immunoglobulins and glucocorticoids require further investigation.
    • Further research is needed to establish risk stratification and optimize treatment strategies for ITP.