Pathophysiology of acute coronary syndromes leading to acute myocardial infarction

Acute coronary syndromes, including unstable angina, myocardial infarction, and sudden death, account for more than 250,000 deaths annually. They are the manifestation of a progressive atherosclerotic process, which culminates in the rupture of atherosclerotic plaques and the formation of mural thrombi. This article reviews recent and current research, which has shed light on key events and evolutionary processes leading to acute coronary syndromes. The article details the development of vulnerable plaques, factors that promote plaque rupture, and triggering events related to plaque rupture. Also discussed are sequelae of acute coronary syndromes, including Q wave and non-Q wave infarction and left ventricular remodeling.