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Updated: Aug 8, 2026

A Comparative Analysis of Recombinant Protein Expression in Different Biofactories: Bacteria, Insect Cells and Plant Systems
Published on: March 23, 2015
The metabolic effects of native and transgenic hemoglobins on plants
L Bülow1, N Holmberg, G Lilius
1Department of Pure and Applied Biochemistry, Center for Chemistry and Chemical Engineering, Lund, Sweden. Leif.Bulow@tbiokem.lth.se
Abstract:
The strictly aerobic bacterium Vitreoscilla expresses a hemoglobin-like protein, VHb, when subjected to oxygen stress. When expressed in plants, this has several intriguing physiological effects, such as improving the overall growth rate, speeding germination and flowering, and increasing the productivity of certain oxygen-requiring metabolic pathways. Although the mechanisms behind the effects of VHb in heterologous hosts are not yet fully characterized, it has been suggested that VHb facilitates oxygen transport and/or storage. This hypothesis is supported by the kinetic properties of VHb, which allow very rapid dissociation of oxygen from the protein.
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