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Genetic optimization of recombinant glycoprotein production by mammalian cells
M Fussenegger1, J E Bailey, H Hauser
1Institute of Biotechnology, ETH Hönggerberg, Zurich, Switzerland.
Trends in Biotechnology
|March 31, 1999
Abstract:
Genetically modified mammalian cells are the preferred system for the production of recombinant therapeutic glycoproteins. Other applications include engineering of cell lines for drug screening and cell-based therapies, and the construction of recombinant viruses for gene therapy. This article highlights contemporary core genetic technologies and emerging strategies for genetically engineering mammalian cells for optimal recombinant-protein expression.