Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data.

J S van der Linde-Sipman1, T S van den Ingh, J J van nes

  • 1Department of Pathology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. thi@dgk.ruu.nl

Veterinary Pathology
|March 31, 1999
PubMed
Summary

A 1996 outbreak of toxic polyneuropathy in cats was linked to contaminated dry cat food. Analysis confirmed salinomycin in the food, causing lameness and paralysis in affected felines.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Repeated measurements of P retention in ponies fed rations with various Ca:P ratios.

Journal of animal science·2014
Same author

Removal of vibrissae in male mice does not influence social dominance.

Behavioural processes·2014
Same author

Relationships between dietary fatty acid composition and either melting point or fatty acid profile of adipose tissue in broilers.

Meat science·2011
Same author

Mathematical relationships between the intake of n-6 and n-3 polyunsaturated fatty acids and their contents in adipose tissue of growing pigs.

Meat science·2011
Same author

Effect of dietary fat type on meat quality and fatty acid composition of various tissues in growing-finishing swine.

Meat science·2011
Same author

Effect of dietary fat sources on fatty acid deposition and lipid metabolism in broiler chickens.

Poultry science·2010

Area of Science:

  • Veterinary Toxicology
  • Animal Neurology

Background:

  • An outbreak of toxic polyneuropathy affected cats in the Netherlands in April 1996.
  • The condition was associated with consumption of specific dry cat food brands from a single manufacturer.

Purpose of the Study:

  • To investigate the cause of a toxic polyneuropathy outbreak in cats.
  • To identify the toxic agent and its effects on affected animals.

Main Methods:

  • Epidemiologic and clinical data were collected from 823 cats.
  • Chemical analyses were performed on cat food, stomach contents, and tissues (liver, kidney) of affected cats.
  • Postmortem examinations were conducted on 21 affected cats.

Main Results:

  • Salinomycin, an ionophor, was identified as a contaminant in the dry cat food.

Related Experiment Videos

  • Affected cats exhibited acute lameness and paralysis, progressing from hindlimbs to forelimbs.
  • Pathologic examinations confirmed a distal polyneuropathy affecting both sensory and motor nerves.

    • Conclusions:

    • Dry cat food contaminated with salinomycin caused toxic polyneuropathy in cats.
    • Salinomycin contamination is a significant risk factor for feline neurological disease.
    • This outbreak highlights the importance of rigorous quality control in pet food manufacturing.