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(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents
M Nomura1, S Kinoshita, H Satoh
1Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Tochigi, Japan.
Bioorganic & Medicinal Chemistry Letters
|March 31, 1999
Abstract:
A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure-activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4-(trifluorome thyl)-phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.