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Allosteric modulators of the AMPA receptor: novel 6-substituted dihydrophthalazines
X F Pei1, M A Sturgess, C F Valenzuela
1Bearsden Bio, Inc., Aston, PA 19014, USA.
Bioorganic & Medicinal Chemistry Letters
|March 31, 1999
Abstract:
Novel analogs of the allosteric AMPA receptor modulator SYM 2206 have been prepared. Structure/activity correlations of these novel analogs and other dihydrophthalazines (DHPs) reveal the important contribution of the heteroatom-based aryl substituents in this class of noncompetitive inhibitors. One of the analogs (6, SYM 2189) is equipotent with the early series, but with reduced sedation.