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Propionic acid production by extractive fermentation. I. Solvent considerations.

Z Gu1, B A Glatz, C E Glatz

  • 1Department of Chemical Engineering, Iowa State University, Ames, Iowa 50011-2230, USA.

Biotechnology and Bioengineering
|April 1, 1999
PubMed
Summary
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Researchers optimized propionic acid extraction by selecting a non-toxic solvent system. Strategies included using vegetable oils or replacing toxic solvents, ensuring efficient recovery of propionic acid.

Area of Science:

  • Biochemical Engineering
  • Industrial Microbiology

Background:

  • Extractive fermentation is crucial for producing organic acids like propionic acid.
  • Selecting appropriate solvents is key to maximizing yield and minimizing toxicity.

Purpose of the Study:

  • To identify optimal solvent systems for propionic acid extractive fermentation.
  • To mitigate solvent toxicity to propionibacteria and ensure efficient acid recovery.

Main Methods:

  • Evaluated Alamine 304-1 with 2-octanol, 1-dodecanol, and Witcohol 85 NF for propionic acid extraction.
  • Screened five propionibacteria strains for solvent resistance.
  • Employed vegetable oils (corn, olive, soybean) for solvent entrapment and Witcohol 85 NF as a non-toxic alternative.
  • Utilized vacuum distillation for acid recovery.

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Main Results:

  • 2-octanol showed high partition coefficient but significant toxicity.
  • A solvent-resistant strain was identified.
  • Vegetable oils reduced toxicity, and Witcohol 85 NF eliminated it.
  • Complete recovery of propionic acid was achieved using Alamine 304-1/Witcohol 85 NF.

Conclusions:

  • Witcohol 85 NF is a viable, non-toxic alternative solvent for propionic acid extractive fermentation.
  • Combined strategies effectively address solvent toxicity and enable efficient product recovery.