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Solution-phase simultaneous addition of functionalities (SPSAF) and chemical transformation to prepare

P P Kung¹, P D Cook

¹Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Calsbad, California 92008, USA.

Biotechnology and Bioengineering

|April 1, 1999

Abstract:

Several piperazine libraries were prepared using solution phase simultaneous addition of functionalities methodology as well as the "library from library" concept. The resulting piperazine libraries displayed antimicrobial activity against both gram-positive and gram-negative bacteria.

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