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Regulation of natriuretic peptide secretion by the heart

G Thibault1, F Amiri, R Garcia

  • 1Laboratory of Cell Biology of Hypertension, Clinical Research Institute of Montreal, Quebec, Canada. Thibaug@ircm.umontreal.ca

Annual Review of Physiology
|April 1, 1999
PubMed

Insights

Natriuretic peptides, secreted by the heart, regulate blood pressure and fluid balance. Key triggers for their release include atrial stretch, adrenergic stimulation, and endothelin, all involving intracellular calcium.

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Molecular Biology

Background:

  • Natriuretic peptides are crucial hormones secreted by the heart, regulating blood pressure and water-salt balance.
  • Their secretion is primarily from atrial cardiomyocytes but also ventricular myocytes during cardiac hypertrophy.
  • Studying natriuretic peptide secretagogues is challenging due to constant atrial hemodynamic changes and contractions.

Purpose of the Study:

  • To elucidate the major triggering agents and mechanisms of natriuretic peptide release.
  • To understand the role of intracellular calcium homeostasis in regulating natriuretic peptide secretion.

Main Methods:

  • Investigated stimuli such as atrial stretch via mechano-sensitive ion channels.
  • Examined adrenergic stimulation through alpha 1A-adrenergic receptors.
  • Analyzed endothelin's role via ETA receptor subtype and other modulators like angiotensin II and prostaglandins.

Main Results:

  • Identified atrial stretch, alpha 1A-adrenergic stimulation, and ETA receptor-mediated endothelin signaling as key triggers for natriuretic peptide release.
  • Demonstrated that angiotensin II and beta-adrenergic agents modulate release via local prostaglandin generation.
  • Highlighted the central role of intracellular calcium homeostasis in controlling natriuretic peptide secretion.

Conclusions:

  • Natriuretic peptide release is orchestrated by multiple signaling pathways, including mechanical, hormonal, and receptor-mediated events.
  • Intracellular calcium dynamics are fundamental to the regulation of natriuretic peptide secretion.
  • Understanding these mechanisms is vital for managing cardiovascular and fluid balance disorders.

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