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Indinavir-induced nephropathy.

D W Grabe1, G Eisele, C Miller

  • 1Albany College of Pharmacy, N.Y., USA.

Clinical Nephrology
|April 1, 1999
PubMed
Summary
This summary is machine-generated.

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A patient taking indinavir, an HIV protease inhibitor, experienced kidney problems due to crystal deposition in the kidneys. Discontinuing the drug resolved the renal insufficiency, highlighting indinavir nephropathy risks.

Area of Science:

  • Nephrology
  • Pharmacology
  • Virology

Background:

  • Protease inhibitors are crucial in managing HIV infection.
  • Indinavir is a protease inhibitor used in antiretroviral therapy.
  • Nephrotoxicity is a potential adverse effect of certain antiretroviral drugs.

Observation:

  • A 38-year-old male on indinavir presented with progressive renal insufficiency over one year.
  • The patient exhibited elevated serum creatinine and abnormal urinalysis.
  • Renal biopsy revealed significant tubular crystal deposition.

Findings:

  • The observed renal insufficiency was directly linked to indinavir use.
  • Cessation of indinavir led to normalization of renal function within two months.
  • This case represents the second documented instance of indinavir-associated nephropathy.

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Implications:

  • Clinicians should monitor renal function in patients using indinavir.
  • Early detection and drug discontinuation can reverse indinavir nephropathy.
  • This case underscores the importance of understanding drug-induced kidney injury in HIV treatment.