Related Experiment Video
Updated: Jul 31, 2026

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
Published on: May 23, 2025
The photic sneeze reflex and ocular anesthesia
I F Wessels1, D A Wessels, G J Zimmerman
1Department of Ophthalmology, Chattanooga Unit, College of Medicine, University of Tennessee, USA.
Background And Purpose:
Intravenous sedation to minimize discomfort from local anesthetic injection has many potential complications including severe involuntary sneezing (i.s.). This prospective study evaluates the occurrence of i.s. and a history of photic sneezing (p.s.).
Methods And Materials:
All patients receiving local anesthesia (retrobulbar or periocular injections) after intravenous thiopentone for eye surgery during eight months were asked about p.s. and observed for i.s.
Results:
The 557 patients (40% males) had a mean age of 69.9 years and 14% recalled p.s. (29.5% males). I.s. developed in 5.2% of the 557. Only 7.6% of those with p.s. developed i.s. After periocular injections 23.8% developed as compared to 4.5% after retrobulbar injections. (P < 0.001). There was no relationship between p.s. and i.s. (p = 0.43).
Conclusion:
I.s. is not linked to p.s., with males and females at equal risk for either. I.s. is more common after periocular injections.
Related Concept Videos
Glaucoma: Overview
Angle Closure Glaucoma: Treatment
Anatomy of the Eyeball
Photoreceptors and Visual Pathways
Ophthalmic Drug Delivery Systems

