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Biological vascular grafts.

K Wengerter1, H Dardik

  • 1Institute of Vascular Surgery, Englewood Hospital and Medical Center, NJ 07631, USA.

Seminars in Vascular Surgery
|April 1, 1999
PubMed
Summary
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Biological bypass grafts, like umbilical vein grafts, offer an alternative to autogenous veins for lower extremity revascularization. Glutaraldehyde treatment enhances graft strength and reduces immune rejection, showing promising long-term patency and limb salvage rates.

Area of Science:

  • Vascular Surgery
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Biological bypass grafts are alternatives to autogenous veins in lower extremity revascularization.
  • Graft failure is often due to immunogenicity and biodegradation.
  • Cryopreservation and glutaraldehyde tanning are methods to improve graft viability and reduce immune response.

Purpose of the Study:

  • To evaluate the efficacy of biological bypass graft materials, specifically umbilical vein grafts, as alternatives to autogenous vein grafts.
  • To assess the impact of glutaraldehyde tanning on graft antigenicity, tensile strength, and sterilization.
  • To report long-term patency and limb salvage rates for umbilical vein grafts.

Main Methods:

  • Utilizing cryopreserved umbilical vein grafts pretreated with dimethylsulfoxide.

Related Experiment Videos

  • Employing glutaraldehyde tanning to enhance graft properties.
  • Analyzing 5-year patency and cumulative limb salvage data.

    • Main Results:

    • Glutaraldehyde tanning effectively increases tensile strength, masks antigenicity, and sterilizes the umbilical vein graft.
    • The 5-year patency rate for these grafts was 67%.
    • Cumulative limb salvage rates reached 80% over 5 years.

    Conclusions:

    • Umbilical vein grafts, processed with glutaraldehyde tanning, represent an effective alternative to autogenous vein grafts.
    • These grafts demonstrate significant long-term utility, evidenced by high patency and limb salvage rates.
    • Addressing immunogenicity and biodegradation is crucial for successful biological bypass graft applications.