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Endothelial cell transplantation.

P Zilla1, M Deutsch, J Meinhart

  • 1Department of Cardiothoracic Surgery, University of Cape Town, South Africa.

Seminars in Vascular Surgery
|April 1, 1999
PubMed
Summary
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Autologous endothelial cell transplantation onto synthetic vascular prostheses leads to persistent endothelial layers. Clinical trials show improved patency rates, especially for below-the-knee grafts, compared to non-endothelialized options.

Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Tissue Engineering

Background:

  • Debate on optimal endothelialization methods for synthetic vascular prostheses.
  • Established consensus on effective endothelial layer creation.

Purpose of the Study:

  • To evaluate the long-term efficacy of endothelialized synthetic vascular prostheses.
  • To compare patency rates of endothelialized versus non-endothelialized grafts.

Main Methods:

  • In vitro endothelialization using cultured venous endothelial cells.
  • Mixed microvascular sodding for luminal tissue layer development.
  • Clinical trials involving nearly 200 in vitro endothelialized prostheses.

Main Results:

Related Experiment Videos

  • Achieved equilibrated luminal tissue layers with persistent endothelium.
  • Demonstrated distinctly better patency results in endothelialized prostheses.
  • Observed superior outcomes particularly in below-the-knee grafts.

    • Conclusions:

    • Both in vitro endothelialization and microvascular sodding create effective endothelial layers.
    • Endothelialized prostheses offer significant patency advantages over non-endothelialized ones.
    • Long-term clinical data support the use of endothelialized grafts in vascular reconstruction.