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Related Experiment Videos

[Injectable progesterone in hormone replacement therapy in menopause].

F Patacchiola1, G Porzio, G Carta

  • 1Dipartimento di Discipline Chirurgiche, Università degli Studi de L'Aquila, Italia.

La Clinica Terapeutica
|April 1, 1999
PubMed
Summary

Intramuscular 17-alpha-hydroxyprogesterone caproate (Lentogest-Amsa) effectively manages menopausal hormone replacement therapy, showing good tolerability and patient compliance, especially with a single monthly dose.

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Area of Science:

  • Reproductive Endocrinology
  • Pharmacology

Background:

  • Menopause is associated with hormonal changes requiring hormone replacement therapy (HRT).
  • Progesterone is a key component in HRT to manage endometrial effects.

Purpose of the Study:

  • To assess the efficacy and tolerability of intramuscular 17-alpha-hydroxyprogesterone caproate (Lentogest-Amsa) for menopausal HRT.
  • To compare outcomes based on different dosing frequencies.

Main Methods:

  • 30 postmenopausal women received intramuscular slow-releasing 17-alpha-hydroxyprogesterone caproate.
  • Participants were divided into groups receiving one or two monthly doses.

Main Results:

  • Consistent monthly bleeding was observed in all participants.

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  • Echographic evaluations confirmed no abnormal endometrial thickening in either group.

    • Conclusions:

    • Intramuscular 17-alpha-hydroxyprogesterone caproate demonstrates efficacy in menopausal HRT.
    • A single monthly dose regimen showed improved patient compliance.