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Related Experiment Videos

Topical phenylephrine increases anal sphincter resting pressure.

E A Carapeti1, M A Kamm, B K Evans

  • 1St Mark's Hospital, Northwick Park, Harrow, UK.

The British Journal of Surgery
|April 1, 1999
PubMed
Summary

Topical phenylephrine gel significantly increases resting anal sphincter pressure in healthy volunteers. This alpha1-adrenergic agonist may offer a new treatment for fecal incontinence caused by low anal sphincter pressure.

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Area of Science:

  • Pharmacology
  • Gastroenterology
  • Anorectal Physiology

Background:

  • Phenylephrine, an alpha1-adrenergic agonist, contracts internal anal sphincter muscle.
  • Animal studies indicate intra-arterial phenylephrine increases resting sphincter pressure.
  • This study investigates topical phenylephrine's effect on human anal pressure.

Purpose of the Study:

  • To evaluate the effect of topical phenylephrine gel on resting anal sphincter pressure.
  • To determine the dose-response relationship of phenylephrine.
  • To assess the duration of action of phenylephrine.

Main Methods:

  • Healthy volunteers received topical phenylephrine gel in increasing concentrations.
  • Maximum resting sphincter pressure (MRP) and blood flow were measured.

Related Experiment Videos

  • Measurements were taken before and after application, and throughout the day.

    • Main Results:

    • A dose-dependent increase in resting anal sphincter pressure was observed.
    • 10% phenylephrine resulted in a 33% rise in MRP (85 to 127 cmH2O).
    • The effect of 10% phenylephrine lasted for a median of 7 hours.

    Conclusions:

    • Topical 10% phenylephrine gel significantly elevates resting anal sphincter pressure.
    • This suggests a potential new therapy for fecal incontinence.
    • The treatment is indicated for cases associated with low resting anal sphincter pressure.