[Evaluation of peritoneal solute transport parameters in diabetics treated with continuous ambulatory peritoneal...

Increasing number of diabetics (D) on CAPD induced us to perform detailed kinetic evaluation of these patients. The purpose of the study was to characterize peritoneal solute transport parameters in diabetics and non-diabetics (ND) treated with CAPD and furthermore to assess clinical implications of eventual differences, especially with regard to programming the long-term CAPD in D. Twelve patients (7D and 5ND) on CAPD for 3-55 months were qualified to the investigation. They were clinically stable, with no impairment of ultrafiltration and free of peritonitis for at least 3 months. Four hours dwell studies with 2.0L of 3.86% glucose dialysis fluid were performed and mass transport coefficients (KBD) for glucose, potassium, sodium, total protein, urea and creatinine were calculated. No statistical differences for KBD between D and ND were found. However for every solute the average KBD values were higher in D that in ND. The observed differences do not justify any different treatment modality for D on peritoneal dialysis (PD). However high SD values, resulting from differences of peritoneal solute transport between patients, indicate the necessity of individualization of PD program.