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Related Concept Videos

Sex-linked Disorders01:43

Sex-linked Disorders

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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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Autism Spectrum Disorder01:19

Autism Spectrum Disorder

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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
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Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
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Social Anxiety Disorder01:28

Social Anxiety Disorder

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Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
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Enzyme-linked Receptors01:00

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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
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Related Experiment Video

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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
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[Rett syndrome as a hodogenesis disorder].

J Narbona1

  • 1Unidad de Neurología Pediátrica, Clínica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, España.

Revista De Neurologia
|April 2, 1999
PubMed
Summary

Rett syndrome is a neurodevelopmental disorder impacting dendrite formation. Recent research explores its origins and neurobiology, offering new insights into this condition.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Context:

  • Rett syndrome is increasingly viewed as a post-migrational neurodevelopmental disorder.
  • The disorder specifically affects dendrite development (dendritogenesis).

Purpose:

  • To review the clinical and chronological patterns of classical Rett syndrome.
  • To discuss recent neurobiological and genetic findings related to the disorder's nature and origin.

Summary:

  • This article examines the clinical progression of Rett syndrome.
  • It delves into current neurobiological and genetic evidence to propose explanations for the disorder's underlying mechanisms and causes.

Impact:

  • Provides a comprehensive overview of Rett syndrome's clinical presentation.

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  • Highlights emerging neurobiological and genetic insights for future research directions.
  • Contributes to a deeper understanding of neurodevelopmental disorders affecting neuronal connectivity.