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Antibiotic-associated colitis: a retrospective study of fifteen cases
Abstract:
Fifteen cases of antibiotic-associated colitis were reviewed in a retrospective study of all the cases seen in a general hospital in the period 1970--7. Nine of these cases were diagnosed as pseudomembranous colitis. This was found mostly in patients over 65 years of age, where it resulted in severe illness with 70% mortality. The antibiotics involved included ampicillin, penicillin, clindamycin, erythromycin and co-trimoxazole (Septrin). Pseudomembranous colitis is a serious hazard in the elderly and may be caused by a wide range of antibiotics in common use.
Insights
Antibiotic-associated colitis, particularly pseudomembranous colitis, poses a severe risk to elderly patients. This condition, linked to common antibiotics, has a high mortality rate in those over 65.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Pharmacology
Background:
- Antibiotic-associated colitis is a significant clinical concern.
- Pseudomembranous colitis is a severe form of this condition.
- The elderly population is particularly vulnerable.
Purpose of the Study:
- To review cases of antibiotic-associated colitis.
- To identify the incidence and characteristics of pseudomembranous colitis.
- To determine the mortality and associated antibiotics.
Main Methods:
- Retrospective study design.
- Review of 15 cases of antibiotic-associated colitis.
- Analysis of patient demographics, clinical presentation, and outcomes.
Main Results:
- Nine cases were diagnosed as pseudomembranous colitis.
- This condition predominantly affected patients over 65 years of age.
- Mortality rate in elderly patients with pseudomembranous colitis was 70%.
Conclusions:
- Pseudomembranous colitis is a serious hazard in the elderly.
- A wide range of commonly used antibiotics can cause this condition.
- Vigilance and awareness are crucial for managing this risk.