Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liquid ventilation attenuates pulmonary oxidative damage.

D M Steinhorn1, M C Papo, A T Rotta

  • 1Department of Pediatrics, Children's Hospital of Buffalo, NY, USA.

Journal of Critical Care
|April 2, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utility of cytokine, adhesion molecule and acute phase proteins in early diagnosis of neonatal sepsis.

Journal of natural science, biology, and medicine·2017
Same author

Prevalence, predictors and outcomes of cardiopulmonary resuscitation in hospitalized adult stem cell transplant recipients in the United States: not just opening the black box but exploring an opportunity to optimize!

Bone marrow transplantation·2015
Same author

Immediate Effects of Use of Recombinant Bone Morphogenetic Protein in Children Having Spinal Fusion and Refusion Procedures in United States.

Spine·2015
Same author

Outcomes of stem cell transplant patients with acute respiratory failure requiring mechanical ventilation in the United States.

Bone marrow transplantation·2014
Same author

Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects.

Diabetologia·2006
Same author

The relationship of fasting serum radioimmune insulin levels to incident coronary heart disease in an insulin-treated diabetic cohort.

The Journal of clinical endocrinology and metabolism·2004
Same journal

Greening critical care by harnessing the planetary impact of medications: What fellows need to know.

Journal of critical care·2026
Same journal

High-dose corticosteroids are associated with higher mortality in patients with COVID-19 ARDS: Results from a nationwide observational study.

Journal of critical care·2026
Same journal

Community-acquired pneumonia outcome is strongly influenced by early arterial pH.

Journal of critical care·2026
Same journal

Measuring attitudes toward death and dying among adult intensive care unit staff: A systematic review of assessment tools.

Journal of critical care·2026
Same journal

Identifying subgroups of ICU patients with high mortality rates using machine learning: A nationwide, population-based study.

Journal of critical care·2026
Same journal

Balanced crystalloids versus saline and mortality in hospitalized patients: a hierarchical Bayesian meta-analysis of cluster-randomized trials.

Journal of critical care·2026
See all related articles

Partial liquid ventilation using perfluorochemicals reduced mortality and lung injury in piglets. This method attenuated oxidative damage by decreasing reactive oxygen species production.

Area of Science:

  • Neonatal Physiology
  • Respiratory Medicine
  • Biochemistry

Background:

  • Alveolar macrophages produce reactive oxygen species.
  • Liquid perfluorochemicals can reduce reactive oxygen species production.

Purpose of the Study:

  • To determine if in vivo liquid ventilation with perfluorochemicals attenuates lung oxidative damage.
  • To assess the impact of partial liquid ventilation on acute lung injury.

Main Methods:

  • Healthy infant piglets with induced acute lung injury were studied.
  • Animals received either conventional mechanical ventilation or partial liquid ventilation with perfluorochemicals.
  • Lung tissue was analyzed for lipid and protein oxidative damage markers (TBARS, carbonylated proteins).

Related Experiment Videos

Main Results:

  • Partial liquid ventilation significantly reduced mortality (0% vs. 50%) compared to conventional ventilation.
  • The partial liquid ventilation group showed improved alveolar-arterial oxygen difference.
  • A 32% reduction in TBARS and 14% reduction in carbonylated proteins were observed in the liquid ventilation group.

Conclusions:

  • Partial liquid ventilation supports gas exchange and reduces mortality in early acute lung injury.
  • This approach is associated with reduced reactive oxygen species production and tissue damage.
  • Perfluorochemical-based partial liquid ventilation shows promise for managing acute lung injury.