Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cobalt proteins.

M Kobayashi1, S Shimizu

  • 1Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan.

European Journal of Biochemistry
|April 2, 1999
PubMed
Summary
This summary is machine-generated.

Cobalt is vital for biological functions, beyond its role in vitamin B12. Researchers are characterizing eight noncorrin-cobalt enzymes, with implications for drug development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HLA matching effect in liver transplantation.

Transplantation proceedings·1992
Same author

Posttransplant donor-specific T-lymphocytotoxic antibody in liver transplant patients with a positive crossmatch.

Transplantation proceedings·1992
Same author

Inhibition of mite protease (Df-protease) with protease inhibitors.

Biochemistry international·1992
Same author

Immunohistochemical detection of Pneumocystis carinii in transbronchial lung biopsy specimens: antigen difference between human and rat Pneumocystis carinii.

Japanese journal of clinical oncology·1992
Same author

Locoregional control for esophageal carcinoma treated with irradiation following surgery.

The Tohoku journal of experimental medicine·1992
Same author

Impaired humoral immunity is associated with development of methicillin-resistant Staphylococcus aureus infections after esophageal surgery.

The Journal of infectious diseases·1992

Area of Science:

  • Bioinorganic Chemistry
  • Biochemistry
  • Enzymology

Background:

  • Cobalt is essential for biological functions, primarily known through vitamin B12.
  • Emerging research highlights cobalt's role in noncorrin-containing proteins.
  • Eight distinct noncorrin-cobalt enzymes have been identified and studied.

Purpose of the Study:

  • To review the biochemistry and bioinorganic chemistry of noncorrin-cobalt enzymes.
  • To understand the function of cobalt transporters in enzyme metallocenter biosynthesis.
  • To explore potential therapeutic applications based on cobalt and nickel transporter differences.

Main Methods:

  • Isolation and characterization of noncorrin-cobalt-containing enzymes.
  • Biochemical and bioinorganic chemistry analyses.

Related Experiment Videos

  • Comparative studies of metal ion transporters.

    • Main Results:

    • Eight noncorrin-cobalt enzymes (e.g., nitrile hydratase, glucose isomerase) have been characterized.
    • A cobalt transporter is crucial for nitrile hydratase's metallocenter formation.
    • Differences between cobalt and nickel transporters are being investigated.

    Conclusions:

    • Cobalt's biological significance extends beyond vitamin B12.
    • Noncorrin-cobalt enzymes represent a diverse functional group.
    • Understanding metal transporters may yield new treatments for gastritis and peptic ulcers.