Related Experiment Videos
Potentiation of isoniazid activity against Mycobacterium tuberculosis by melatonin
I Wiid1, E Hoal-van Helden, D Hon
1MRC Centre For Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch Medical School, Tygerberg, South Africa.
Antimicrobial Agents and Chemotherapy
|April 2, 1999
Abstract:
The limited number of effective antituberculosis drugs available necessitates optimizing current treatments. We show that melatonin, which is synthesized in the pineal gland, can cause at least a threefold increase in the efficacy of isoniazid. This suggests that tuberculosis chemotherapy can be improved by innate molecules such as melatonin.