Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Influence of some cytostatics on leucocyte function.

R Neuwirtová, O Setková, V Dorazilová

    Haematologia
    |January 1, 1976
    PubMed
    Summary

    This study investigated how daunorubicin and vincristine affect white blood cell functions in leukemia patients. While vincristine reduced phagocytosis, neither drug impacted the cells' ability to kill Candida, suggesting preserved immune function.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Surgical results in patients with CNS lymphoma. Comparison of predictive value of intraoperative MRI and intraoperative histological examination for diagnostic biopsy yield.

    Brain & spine·2024
    Same author

    Sequencing-based analysis of clonal evolution of 25 mantle cell lymphoma patients at diagnosis and after failure of standard immunochemotherapy.

    American journal of hematology·2023
    Same author

    Clinical value of ALK and CD30 expression in mature systemic T cell lymphomas: analysis from the Czech Lymphoma Study Group database (NIHIL).

    Annals of hematology·2022
    Same author

    PD-1, PD-L1 and PD-L2 Expression in Mantle Cell Lymphoma and Healthy Population.

    Folia biologica·2021
    Same author

    Anti-CD38 Therapy with Daratumumab for Relapsed/Refractory CD20-Negative Diffuse Large B-Cell Lymphoma.

    Folia biologica·2020
    Same author

    Cyclin D1 mRNA as a molecular marker for minimal residual disease monitoring in patients with mantle cell lymphoma.

    Annals of hematology·2017

    Area of Science:

    • Hematology
    • Immunology
    • Pharmacology

    Background:

    • Acute leukemia patients often have compromised immune systems.
    • Chemotherapy agents like daunorubicin and vincristine are used to treat leukemia.
    • Understanding the impact of these drugs on immune cell function is crucial for patient care.

    Purpose of the Study:

    • To evaluate the in vitro effects of daunorubicin and vincristine on phagocytic activity, nitroblue tetrazolium (NBT) reduction, and candidacidal capacity of leucocytes.
    • To compare the effects of these cytostatics on leucocytes from normal individuals and acute leukemia patients.

    Main Methods:

    • In vitro study using whole blood from normal subjects and acute leukemia patients.
    • Incubation of blood with solvent only, daunorubicin, or vincristine.
    • Assessment of phagocytic activity, NBT reduction, and candidacidal capacity against Candida.

    Main Results:

    • Daunorubicin induced nuclear changes in leucocytes, but phagocytic capacity remained unchanged or increased.
    • Vincristine reduced phagocytic activity in most cases.
    • Neither daunorubicin nor vincristine significantly altered the nitroblue tetrazolium reduction or the candidacidal capacity of leucocytes.

    Conclusions:

    • Leucocyte phagocytic activity is differentially affected by daunorubicin and vincristine.
    • The candidacidal capacity of leucocytes is resistant to the effects of daunorubicin and vincristine.
    • These findings suggest that key immune functions may be preserved during treatment with these cytostatics.

    Related Experiment Videos